The amygdala is a key brain area regulating responses to stress and emotional stimuli, so improving our understanding of how it is regulated could offer novel strategies for treating disturbances in emotion regulation. As we review here, a growing body of evidence indicates that the gut microbiota may contribute to a range of amygdala-dependent brain functions from pain sensitivity to social behavior, emotion regulation, and therefore, psychiatric health. In addition, it appears that the microbiota is necessary for normal development of (...) the amygdala at both the structural and functional levels. While further investigations are needed to elucidate the exact mechanisms of microbiota-to-amygdala communication, ultimately, this work raises the intriguing possibility that the gut microbiota may become a viable treatment target in disorders associated with amygdala dysregulation, including visceral pain, post-traumatic stress disorder, and beyond. Also see the video abstract here: https://youtu.be/O5gvxVJjX18 The amygdala plays a central role in regulating many aspects of behavior in rodents and humans, from pain responding to social interaction and psychiatric function. Accumulating evidence suggests microbiota-to-amygdala communication along the gut-brain axis is a key modulator of these amygdala-dependent behaviors, with critical implications for health and disease. (shrink)

Much ink has been spilt in consideration of the once pervasive reliance on military metaphors to depict the relationships between science and religion in the nineteenth century. This has resulted in historically sensitive treatments of secularization; and the realization that the relationship between science and religion was not a bloody war between intellectual nation states, but a protracted divorce of former partners. Moreover, historians of science have been encouraged to throw off the yoke of the internalism–externalism debate, and to explore (...) the cultural boundaries that impinged upon practitioners of a natural knowledge of the world. Within the historiography of nineteenth-century science, this has resulted in many new perspectives on science and natural knowledge in relation to cultural control and authority. (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

In this paper; having somewhat arbitrarily adopted a general line of interpretation of Wittgenstein on forms of life in which the word ’life' is taken in a biological sense, I try to work out ways of being more specific than that, which (a) are philosophically interesting, (b) are consistent with Wittgenstein's uses of the expression form of life' and with other remarks of his that seem closely connected, and (c) that take seriously both his disavowal of THESES in philosophy and (...) his (related) belief that the job of philosophy is not to devise better theories, but to show how the problem itself arises from a particular kind of misunderstanding of language. A number of ways in which the idea of a form of life could play that sort of part are explored, for example the question how we know from which direction a sound comes, which we might initially have supposed to be answerable by reference to a calculation of the time difference in the arrival of a sound wave at one ear and then the other is rejected in favour of a supposition that the waves affect the nervous system and thereby causes us to look in the correct direction. This is an important difference. A neurologist might spend half a lifetime tracking down the nerves that calculate the direction, ana fail because no such calculation is done. Misdirected questions about identifying and locating pains, and about mastery are investigated, and finally Wittgenstein is depicted as holding that the nervous system, together with membership in a community provides all the assurance we need of the general correctness of calculations. (shrink)

In a contemporary developed economy, the production of labor-power is not left to the "laborer's instincts for selfpreservation and of propagation," as in Capital, but is made subject to large-scale institutional investment and control within, primarily, the educational system. Some therefore of the laborer's consumption of goods and services has no longer a "final" character but directly enters into the production of the most important producer commodity, labor-power itself. This constitutes a partial closure of the circuit of producers' capital and, (...) as corollary to the latter, a significant absorption of the once distinct sphere of circulation, or exchange, into that of production, and with it a historical change in the relationships holding between the overall sphere of production and society itself. (shrink)

This paper describes one way in which a precise reason model of precedent could be developed, based on the general idea that courts are constrained to reach a decision that is consistent with the assessment of the balance of reasons made in relevant earlier decisions. The account provided here has the additional advantage of showing how this reason model can be reconciled with the traditional idea that precedential constraint involves rules, as long as these rules are taken to be defeasible. (...) The account presented is firmly based on a body of work that has emerged in AI and Law. This work is discussed, and there is a particular discussion of approaches based on theory construction, and how that work relates to the model described in this paper. (shrink)

Canada has followed the pattern of Benelux nations by legislating sufferingSuffering as the pivotal eligibilityEligibilitycriterionCriterion for euthanasiaEuthanasia/assisted death without requiring terminal prognosis as is needed in most permissive jurisdictions. This chapter will explore the relationship between sufferingSuffering and Medical Assistance in Dying (MAID) and the ways in which sufferingSuffering is understood in the Supreme Court of Canada, the federal Criminal Code legislation and by health care assessors. Based on this analysis, we will argue that the resulting sufferingSufferingeligibilityEligibilitycriterionCriterion leaves the law (...) open to unintended forms of interpretation, thus instituting perhaps the most unbounded and risk-prone form of assisted death in the world. A review of the literature on sufferingSuffering, the wish to dieWish to die, and reasons for MAIDReasons for MAID requests found sufferingSuffering of severe illness to be frequently associated with unstable mental health, social, and existentialExistential variables that are often amenable to therapy or remediation. While sufferingSuffering remains a powerful motivating force to seek opportunities to relieve distress, its use as an eligibilityEligibilitycriterionCriterion for MAID has significant ambiguity in its’ characterization of ‘enduring’ and ‘irremediable’ and thus fails to protect against abuse for the vulnerable. (shrink)

Medicine is faced with a number of intractable modern challenges that can be understood in terms of hyper-intellectualization; a compassion crisis, burnout, dehumanization, and lost meaning. These challenges have roots in medical philosophy and indeed general Western philosophy by way of the historic exclusion of human emotion from human reason. The resolution of these medical challenges first requires a novel philosophic schema of human knowledge and reason that incorporates the balanced interaction of human intellect and human emotion. This schema of (...) necessity requires a novel extension of dual-process theory into epistemology in terms of both intellect and emotion each generating a distinct natural kind of knowledge independent of the other as well as how these two forms of mental process together construct human reason. Such a novel philosophic schema is here proposed. This scheme is then applied to the practice of medicine with examples of practical applications with the goal of reformulating medical practice in a more knowledgable, balanced, and healthy way. This schema’s expanded epistemology becomes the philosophic foundation for more fully incorporating the humanities in medicine. (shrink)

Iamblichus , successor to Plotinus and Porphyry, brought a new religiosity to Neoplatonism. This edition of the fragments of Iamblichus' major work on the soul, De Anima, is accompanied by the first English translation of the work and a commentary.

The study of reputation has often focused on the creation of good reputations rather than on the varied means by which reputations are modified, or shifted, and the factors affecting such shifts. This paper develops a theory of reputation shifting and identifies five basic reputational actions, the types of strategic responses that can be taken to manage reputations.

Although Michael Polanyi's model of science and his construal of the nature of the real are usually thought to be congenial to religion and although Polanyi himself says that “the stage on which we thus resume our full intellectual powers is borrowed from the Christian scheme of Fall and Redemption” (Polanyi 1958, 324), theologians have given little attention to the model of God he presents. The metaphysical and theological vision unfolded in part 4 of Personal Knowledge is a thoughtful alternative (...) to materialist versions of neo‐Darwinism and provides a platform for revisiting four long‐standing controversies at the interface of science and religion: whether life and mind can be completely specified in terms of physical analysis, whether nature can be adequately understood without appeal to final causes, whether natural selection adequately explains life's diverse forms, and whether knowledge can be fully objectified. Through an exploration of Polanyi's contribution to these discussions, we undertake to show not only that his treatment of God as a cosmic field is strikingly original but also that in reinstating activity as a metaphysical category, he reconstructs our understanding of our creaturely hope and calling. (shrink)

The chapter explores the sufferingSufferingassociated with MAIDMedical Assistance in Dying (MAID) giving special attention to assessmentAssessment and the psychological responses elicited in caregivers highlighting the need for all MAIDMedical Assistance in Dying (MAID) enquiries to activate a period of intense assessmentAssessment and the provision of detailed treatment alternatives. This chapter calls for a renewed commitment to compassionCompassion (‘sufferingSuffering together with’) as the communal dynamic to relieve and assuage such sufferingSuffering. Using the four domains of ‘total pain’ (Saunders in The management (...) of terminal malignant disease. Edward Arnold, London, UK, 1978), we summarize the evidence for the multiple opportunities available to ‘relieve often and comfort always.’ Finally, we review evidence on the impactImpactof MAIDMedical Assistance in Dying (MAID) suggesting that the overall burden of sufferingSuffering in Canada has increased since legalization. (shrink)

A normative criterion identifying the conditions for a desirable corporate reputation, “reputational optimality,” or “reputational bliss,” is described, and a case developed for its utility and reasonableness as a criterion to apply to real world phenomena. The paper discusses some behavioral patterns under alternative moral positions taken by observers and the firm, critiques some alternative moral principles, and considers some dynamics of moving toward, defending and maintaining, and breaching or breaking reputational bliss.

This paper develops a two-part model of the crucial roles that episodic memory and perceptual filters play in responses to organizational crisis. We examine thecascading impacts of episodic memory, the types of filters that shape stakeholder responses to crisis, and subsequent impacts on reputation. A sound wave analogy is developed to understand the complexity of organizational crisis. The model is partially applied to the BP Deepwater Horizon oil rig disaster.

Disagreement over the legitimacy of direct sterilization continues within Catholic moral debate, with painful and at times confusing ramifications for Catholic healthcare systems. This paper argues that the medical profession should be construed as a key moral authority in this debate, on two grounds. First, the recent revival of neo-Aristotelianism in moral philosophy as applied to medical ethics has brought out the inherently moral dimensions of the history and current practice of medicine. Second, this recognition can be linked to Catholic (...) morality through Vatican II’s affirmation of the legitimate autonomy of culture, including the sciences. A partial precedent for understanding the moral authority of medicine can be found in the recent history of Catholic medical morality, and we further argue that a full contemporary recognition of that authority would weigh against an absolute prohibition of direct sterilizations. Institutionally, we propose the allowance of direct sterilizations in cases where the clinically perceived biomedical good of the patient is at stake. (shrink)

John F. Kavanaugh and W. Norris Clarke, two twentieth-century Jesuits, contributed to philosophy through their development of a Thomistic and personalist view of reality emphasizing the human endowments of knowing, freely choosing, and loving. While spiritual exercises played a role in the formation of both Jesuits, the function of spiritual exercises in their own philosophy has not been explored. Recent interest in philosophy as a way of life provides a means by which this can be accomplished. In their work (...) Michel Foucault and Pierre Hadot have shown how spiritual exercises function in the formation of the self and in the acquisition of a synoptic vision that allows contemplation of one’s participation in the whole. This paper shows that while Kavanaugh primarily uses spiritual exercises in his philosophy to accomplish a disciplinary/formational aim Clarke’s aim is dialogical/exploratory. A brief examination of the Spiritual Exercises of Ignatius of Loyola reveals how these different aims in fact complement one another. (shrink)

This book assesses how Vatican II opened up the Catholic Church to encounter, dialogue, and engagement with other world religions. Opening with a contribution from the President of the Pontifical Council for Interreligious Dialogue, Cardinal Jean-Louis Tauran, it next explores the impact, relevance, and promise of the Declaration Nostra Aetate before turning to consider how Vatican II in general has influenced interfaith dialogue and the intellectual and comparative study of world religions in the postconciliar decades, as well as the contribution (...) of particular past and present thinkers to the formation of current interreligious and comparative theological methods. Additionally, chapters consider interreligious dialogue vis-à-vis theological anthropology in conciliar documents; openness to the spiritual practices of other faith traditions as a way of encouraging positive interreligious encounter; the role of lay and new ecclesial movements in interreligious dialogue; and the development of Monastic Interreligious Dialogue. Finally, it includes a range of perspectives on the fruits and future of Vatican’s II’s opening to particular faiths such as Judaism, Islam, Hinduism, and Buddhism. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Abailard and the Problem of Universals JOHN F. BOLER ABAILARD t IS A CLEVERman, but in one respect he is just like the rest of us: Given one clear idea of which he is convinced, he tends to become intolerant, thinking the worst of everyone else. Abailard's clear idea goes something as follows. In what does universality consist? It consists, says Abailard, in the signifying of many things (...) by one sign? Abailard's predecessors had been searching for some thing which was universal. But a sign must signify many things to be universal; and furthermore, the sign itself, as a thing--a noise, gesture, or statue--is individual. ~ It may help to describe the model which crops up here and there in Abailard's examples and which, I think, dominates his analysis. Consider, then, a statue which is not meant to stand for any one particular individual: for example, the Minute Man at Concord, Massachusetts.* First of all, the statue is an individual thing. Second, just as a piece of metal, it need not stand for anything--anymore than a bird bath would, had the town council decided to build that instead. What is more, it is information from other sources which leads us to take the statue as "general" rather than as depicting some individual (like Nathan Hale). And even though the statue stands for "all" minute men, not only is the statue an individual thing but all those things for which it stands are (or were) individuals. And finally, we might also point out that the statue must be taken as signifying; it does not have "representative" qualities in quite the same way that it has properties like weight and shape. t The text of Abailard to which I have referred is: Peter Abaelards Philosophische Schrqte, herausgegeben yon Dr. Bernhard Geyer, I Die Logica "Ingredientibus,'" II Die Logica "'Nostrorum Petitioni Sociorum" which is to be found in Beitraege zur Geschichte der Philosophie und Theologie des Mittelalters, Band XXI (1933). A partial translation of this text appears in R. McKeon, Selections from Medieval Philosophers (New York: Scribners, 1929), II, 208-258. Hereafter I shall refer to the latin text as "G" followed by the page number and lines; and to the translation, where possible, as "'M" with the page number. 9Abailard feels that when Aristotle says that a universal is what is fitted for being predicated of many things, it is the signifying of many things which is at stake; and he chides Aristotle for seeming to ascribe universality to things as well as to words. G ~ (M 221). The reference to Aristotle is On Interpretation, 17a (38-40). *See note 7, below. 9I have interpolated on two passages: G 22t~-~ (M 241-242), and G 522*t-=. [37] 38 HISTORY OF PHILOSOPHY The upshot of Abailard's insight is that universality pertains to the interpretation of signs: the effort to locate universal things is misguided. Some want to say that the universal is a collection; but do collections signify their members? ~ Some want to say that the universal is a substance of which individuals are accidents; but is a substance predicated of its accidents? e And some want to say that universals are words--that is noises; but noises are also individual things. ~ In short, to signify or to show ("monstrare") pertains to words; to be signified or shown pertains to things. 8 And to transfer the properties of one to the other leads to hopeless difficulties. ~ One can understand Abailard's exultation (and exaltation) at having shown both sides of a seething controversy to be equally misguided? ~ But what then remains as the problem of universals? It is this: one would expect that every sign would have some subject which it signifies; but universals seem to lack a proper subject. And does this not mean that universals are fictions (like goat-stag or chimera)? = Having thus set out rather baldly what I take to be Abailard's "clear idea," let me now try to show more fully how he goes about establishing the problem and providing for a solution. Abailard's position on universals is set forth in his two logic books, both of which begin... (shrink)

I begin by reconsidering the arguments of John Taurek and Elizabeth Anscombe on whether the number of people we can help counts morally. I then consider arguments that numbers should count given by F. M. Kamm and Thomas Scanlon, and criticism of them by Michael Otsuka. I examine how different conceptions of the moral method known as pairwise comparison are at work in these different arguments and what the ideas of balancing and tie-breaking signify for decision-making in various types (...) of cases. I conclude by considering how another moral method that I call virtual divisibility functions and what it helps reveal about an argument by Otsuka against those who do not think numbers count. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:NOTES AND DISCUSSIONS 95 OCKHAM ON INTUITIVE COGNITION t In the first part of what follows, I try to locate Ockham's theory of intuitive cognition in the context of one set of philosophical problems rather than another. The device I use is to emphasize the major error Ockham wants to avoid: "platonism" rather than scepticism. In the second part, I try to show how difficulties raised by some recent (...) commentary result from the wrong orientation. This very limited project involves neither exposition nor assessment of Ockham's proposed solutions for the philosophical problems. But hopefully it will prove useful or at least suggestive for others working in this or related areas in Ockham. According to Ockham, 2 someone can be said to hold to or cognize a proposition evidently when he knows it to be true. The paradigm of knowing something to be true is seeing that it follows from the premisses in a demonstrative syllogism. However, first principles, or any proposition per se nota, can also be known to be true or cognized evidently. And, what is most important for our purposes, contingent propositions can be cognized evidently when, as one might say, they are known in experience. When someone is looking at a white wall, to ~se one of Ockham's examples, he can cognize evidently the proposition "The wall is white." 3 i Aside from a few quotations, I have given only the location of references in Ockham. Only very extensive quotations would make the article self-sufficient or, for that matter, even be helpful to the reader. My effort is both tentative and parasitic on earlier commentary and can, perhaps, be excused from providing logistic support that would far exceed its own weight. Moreover, I have tried to direct the reader to the most convenient materials, using fairly common or obvious abbreviations for Ockham's writings and the symbols given in the brackets for each of these sources. [Baudry] L Baudry, Lexique philosophique de Guillaume d'Ockham (Paris, 1958). [McKeon] R. McKeon, Selections /tom Medieval Philosophers, Vol. II (New York, 1929). This almost literal translation of selected Quodlibeta is sufficient for my present purposes. The Strasbourg edition of 1491, of course, is not more readily available m the reimpression from Louvain, Editions de la Biblioth~que Sd., 1962. [OPW] P. Boehner, Ockham: Philosophical Writings (New York, 1957). The page numbers given are from the Nelson edition, containing both Latin and English. The Library of Liberal Arts (Bobbs-Merrill) edition which consists only of the English text runs from one to sixteen pages ahead as a result of numbering the blank pages at the beginning of each section. [Ordinatio] Opera Philosophica et Theologica (St. Bonaventure, N.Y., 1967). Vol. I: Scripture in Librum Primum Sententiarum Ordinatio, Prologus et Distinctio Prima, edited by G. Gal and S. Brown. The lines referred to are given as superscripts to the page numbers. a Expos. Physicorum, Prologue ([OPW] pp. 4-5). See also [Baudry] under scire and evidens. a The issue of translation raises a host of problems of varying degrees of philosophical importance. I am not settled in my own mind about the best English equivalents for many important terms, and in my translations and commentary I have not tried for consistency. In principle, I prefer odd or quaint terms, since they bear their faults on their 96 HISTORY OF PHILOSOPHY At one point, Ockham gives this description: Whoever knows some proposition evidently cannot dissent from that proposition by the power of the will alone, but it is necessary that he be persuaded by an argument more strongly moving his intellect to dissent, or it is necessary that he have forgotten something evidently known.4 Let me call your attention to the un-Cartesian way in which Ockham removes the judgement of some contingent (and all necessary) propositions from the (total) dominion of the will. I may remain silent or talk of something else, or I may avail myself of questions and conditionals, but if I intend to deal head-on with equals added to equals or (while looking at the white wall) with walls and whiteness, I cannot but assert that equals added to equals are equal or... (shrink)